TB-500
Same price per vial — no bulk discount, just add more to one order.
20% off included — code WELCOME20 is reflected in this price and applied automatically at checkout.
For laboratory research use only · Not for human consumption · Read handling terms →
Lab-grade material. Proof in every order.
Third-party HPLC, mass-spec, and endotoxin testing on every batch — with the Certificate of Analysis included, not on request.
Overview+
TB-500 is a synthetic version of the central active fragment of thymosin beta-4. It is studied for its involvement in actin binding, cell migration, and tissue remodeling, with much of the research interest centered on wound-healing and angiogenesis models. As a defined synthetic fragment it gives researchers a consistent reagent for interrogating cytoskeletal behavior.
History+
Thymosin beta-4 was first isolated from thymus tissue in the early 1980s. Its actin-binding region was later synthesized as TB-500, which became a widely used reagent for studying cytoskeletal dynamics and repair-associated signaling. Isolating the active fragment allowed researchers to work with a smaller, more tractable molecule while retaining the properties most relevant to remodeling research.
Structure & specifications+
Research findings+
TB-500 has been studied across structural, vascular, and epithelial models for activity on G-actin sequestration, F-actin dynamics, angiogenic signaling, and re-epithelialization kinetics. Because actin regulation sits upstream of both migration and structural repair, TB-500 is treated as a probe for the earliest mechanical stages of tissue remodeling. Its consistency across model systems is what makes it a durable tool for characterizing cytoskeletal and angiogenic pathways in the laboratory.
- →Structural: Cytoskeletal remodeling, ECM dynamics
- →Vascular: Angiogenesis, endothelial behavior
- →Epithelial: Cell migration, re-epithelialization
- →Systemic: Anti-inflammatory and oxidative-stress signaling
Shipping, storage & handling+
Same-day dispatch before 2:00 PM CST, Monday through Saturday. Store lyophilized vials at −20°C, protected from light; reconstituted solutions at 2–8°C. Discreet, temperature-safe packaging. Guaranteed delivery with free reshipment.
References+
- Goldstein AL. et al. (2005). Thymosin beta-4 in tissue protection and repair.
- Malinda KM. et al. (1999). Thymosin beta-4 and endothelial cell migration.
- Huff T. et al. (2001). Thymosin beta-4 as an actin-sequestering peptide.
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