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Fast Track Labs

TB-500

CAS #: 77591-33-4
Research Use Only

Supplied strictly for in-vitro and laboratory research. Not for human or veterinary use. By ordering, you confirm you are a qualified researcher handling these materials per applicable regulations and safe lab practice.

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TB-500
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$69.00
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Batch-specific Certificate of Analysis included with every shipment — third-party tested for 99.6% purity, ID, and quantity.

TB-500 Overview

TB-500 is a synthetic version of the central active fragment of thymosin beta-4. It is studied for its involvement in actin binding, cell migration, and tissue remodeling, with much of the research interest centered on wound-healing and angiogenesis models. As a defined synthetic fragment it gives researchers a consistent reagent for interrogating cytoskeletal behavior.

History

Thymosin beta-4 was first isolated from thymus tissue in the early 1980s. Its actin-binding region was later synthesized as TB-500, which became a widely used reagent for studying cytoskeletal dynamics and repair-associated signaling. Isolating the active fragment allowed researchers to work with a smaller, more tractable molecule while retaining the properties most relevant to remodeling research.

TB-500 Structure

CAS #: 77591-33-4
Formula: C₂₁₂H₃₅₀N₅₆O₇₈S
MW: 4963.44 g/mol
PubChem ID: 16132341

Research Findings

TB-500 has been studied across structural, vascular, and epithelial models for activity on G-actin sequestration, F-actin dynamics, angiogenic signaling, and re-epithelialization kinetics. Because actin regulation sits upstream of both migration and structural repair, TB-500 is treated as a probe for the earliest mechanical stages of tissue remodeling. Its consistency across model systems is what makes it a durable tool for characterizing cytoskeletal and angiogenic pathways in the laboratory.

Key Areas of Research:
  • →Structural: Cytoskeletal remodeling, ECM dynamics
  • →Vascular: Angiogenesis, endothelial behavior
  • →Epithelial: Cell migration, re-epithelialization
  • →Systemic: Anti-inflammatory and oxidative-stress signaling

References

  • Goldstein AL. et al. (2005). Thymosin beta-4 in tissue protection and repair.
  • Malinda KM. et al. (1999). Thymosin beta-4 and endothelial cell migration.
  • Huff T. et al. (2001). Thymosin beta-4 as an actin-sequestering peptide.

Our Process

STEP 01
Precision Lyophilization

Manufactured in a controlled U.S. facility under strict compounding standards.

STEP 02
Verified Purity

Every batch third-party tested with HPLC and mass spectrometry.

STEP 03
Same-Day Fulfillment

Orders dispatched same-day from our U.S. facility.

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Frequently Asked Questions

Everything you need to know about our products and processes.

What's the actual amount in each vial?+
Each vial contains the labeled mass of lyophilized peptide. Selected sizes appear above the price.
Are additional supplies needed?+
Reconstitution requires bacteriostatic water, sterile syringes, and appropriate research labware – not included.
How long does a vial last?+
Sealed lyophilized vials are stable at −20°C for 24 months. Once reconstituted, store at 2–8°C and use within 28 days.
Does the product come with instructions?+
Each shipment includes the batch-specific Certificate of Analysis and recommended handling protocol.
What purity level is guaranteed?+
≥ 99% by reverse-phase HPLC (UV-220nm), confirmed via ESI-TOF mass spectrometry.
How should I store these products?+
Store sealed vials at −20°C, protected from light. Reconstituted solutions at 2–8°C.
What are peptides and how do they work?+
Peptides are short chains of amino acids that occur naturally in organisms, where they act as messengers in many biological systems. While some peptides have been developed for medical use, laboratory research focuses on understanding their activity at the cellular level, examining how they impact essential processes in vitro.
Do these products come with instructions?+
Products from Fast Track Labs are supplied without usage instructions, as they are designated solely for in vitro laboratory research and prohibited by law for human or animal consumption. Any misuse or unlawful application of these products will result in permanent denial of service.
How long do products take to deliver?+
Orders are typically processed and shipped within 24 hours on weekdays. Delivery times vary by location, but most domestic orders arrive within 3–5 business days. You'll receive tracking information as soon as your order ships.
TB-500
$69.00