Customers can verify COA's here: https://horizonanalytical.com/verify-coa
Supplied strictly for in-vitro and laboratory research. Not for human or veterinary use. By ordering, you confirm you are a qualified researcher handling these materials per applicable regulations and safe lab practice.
Customers can verify COA's here: https://horizonanalytical.com/verify-coa
Nicotinamide adenine dinucleotide is an essential coenzyme at the center of cellular energy metabolism and redox reactions. Research explores its role in mitochondrial function, DNA-repair signaling, and sirtuin-dependent pathways, where it acts both as an electron carrier and as a substrate consumed by signaling enzymes.
First described in the early 20th century under the name "cozymase," NAD+ has been a cornerstone of biochemistry for more than a hundred years. Renewed research interest has shifted toward how it is synthesized, how its levels decline with age, and its function as a substrate for enzymes such as sirtuins and PARPs, moving it from a classical metabolic cofactor to an active subject in aging and signaling research.
NAD+ has been studied across metabolic and cellular models for redox cycling, sirtuin- and PARP-dependent signaling, mitochondrial function, and energy-homeostasis pathways. Its dual role, cycling as a redox carrier while also being consumed by signaling enzymes, is what makes it a recurring focus in both bioenergetics and aging research. As one of the most fundamental cofactors in the cell, it serves as a central reference molecule for studying energy homeostasis and enzyme-driven signaling.
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