MOTS-c
Same price per vial — no bulk discount, just add more to one order.
20% off included — code WELCOME20 is reflected in this price and applied automatically at checkout.
For laboratory research use only · Not for human consumption · Read handling terms →
Lab-grade material. Proof in every order.
Third-party HPLC, mass-spec, and endotoxin testing on every batch — with the Certificate of Analysis included, not on request.
Overview+
MOTS-c is a mitochondrial-derived peptide studied for its role in metabolic regulation and the cellular stress response. Research focuses on its influence on insulin sensitivity, AMPK signaling, and mitochondrial homeostasis, placing it among a distinct class of peptides encoded within the mitochondrial genome rather than the nucleus.
History+
Identified in the mid-2010s as a mitochondrial-encoded regulator, MOTS-c was characterized as a mitokine, a signal originating in the mitochondria that translocates to the nucleus and influences adaptive gene expression. Later work examined its involvement in exercise responses and metabolic stress, expanding interest in mitochondrial-to-nuclear communication.
Structure & specifications+
Research findings+
MOTS-c has been examined in metabolic models for AMPK-pathway activation, glucose handling, insulin-sensitivity signaling, and exercise-associated adaptation. Its identity as a mitokine is the central research theme, since it offers a model for how mitochondria signal metabolic state to the rest of the cell. That makes MOTS-c a useful tool for studying the intersection of energy metabolism, stress adaptation, and gene regulation in the laboratory.
- →Metabolic: AMPK signaling, glucose regulation
- →Mitochondrial: Mitokine dynamics, nuclear gene expression
- →Systemic: Physical-capacity and aging-related pathways
Shipping, storage & handling+
Same-day dispatch before 2:00 PM CST, Monday through Saturday. Store lyophilized vials at −20°C, protected from light; reconstituted solutions at 2–8°C. Discreet, temperature-safe packaging. Guaranteed delivery with free reshipment.
References+
- Lee C. et al. (2015). Characterization of a mitochondrial-derived metabolic peptide.
- Reynolds JC. et al. (2021). Exercise-associated regulator of metabolic homeostasis.
- Kim KH. et al. (2018). Mitochondrial-peptide signaling in metabolic stress.
What’s actually in your vial?
Most researchers don’t ask. The ones who do, switch.
Text us, our dedicated team is here to help.
Reach out and get a response within minutes.